South Park - The Stick of Truth created by Ubisoft.
Images used for educational purposes only.
Main Walkthrough

Good 'ol Jimbo. Even with the fate of the world at stake, he's always ready and willing to kill a few animals. He also wants kids to get in on the action, as early as he can brand 'em with the hunting allure, and Big Game Huntin' With Jimbo puts you into Jimbo's shoes to hunt down some of the roughest, toughest, meanest critters this side of Scott Tenorman.
Location
All you have to do to unlock Big Game Huntin' With Jimbo is to speak to the man. He always hangs out at Jimbo's Guns, located in northwest South Park. Once there, purchase Hunter's Guide to South Park's Wildlife for $3.00 to trigger the quest. In doing so you'll earn six additional items - Blood Orange, Cow Bell, Fromunda Cheese, Poutine, Rubbing Alcohol, and Moldy Sausage - which will each be used as lures to trap the six beasts in this quest.
Rabid Junkyard Dog
The Rabid Junkyard Dog is found outside Kenny's House. Look to the right of the garage for a mouldering bowl of water. Approach it and use the Moly Sausage to lure the dog out. It will come dashing up and attack. Get in the first swipe before it can bite you.
The Rabid Junkyard Dog is basically a beefed-up version of the dogs you'll find in the woods surrounding South Park. It hits pretty hard and has a lot of HP, but is otherwise a simple enough fight. Riddle it with status ailments and debuffs to win the day.
Farm Cow
The Farm Cow is, as you might expect, located at the Farm on the northeastern outskirts of South Park. As soon as you enter the yard you'll see a small gate latch beside the entrance. Approach it and you can hook the Cow Bell to it. The Farm Cow will come wandering up. Whack it once to take it out. Yep, no fight required on this one.
... Something Mouse
The Mouse (no, I'm not saying its full name, you know what it is) is found in South Park's sewers. Look for an upward ladder blocked by bars; you can use the Fromunda Cheese in the room above to lure out the Mouse.
The Mouse is something of a formidable foe, as its bite can inflict bleeding, grossed out, and slow on your characters with a single strike. Nevertheless, it can be stunned, slowed, bled, and otherwise hobbled. It's also cursed with a rather low amount of HP. Just make sure you hit it before it hits you and you can maul it badly on your first turn, possibly killing it before it gets a chance to attack.
Bloodsucking Fruit Bat
The Fruit Bat is hidden in the sewers. Make your way through here until you find the realm of the Crab People, a long, blueish cave. Near the ladder leading out of here is a stalagmite you can bust through. Past it is the luring spot where you can set down the Blood Orange.
The Fruit Bat is pretty easy. It's only annoying in that it can lower everyone's defenses and attack immediately thereafter, though it doesn't hit hard enough to be a real threat. Smack it down with fire damage.
Mutant Bacteria
The Mutant Bacteria hangs out at the School, though that's a woefully-vague description of its location. The School is big. You'll find the Mutant Bacteria in the basement of the School, within its Boiler Room. Head down here during the invasion of the School and use the Rubbing Alcohol on the petri dish that's overflowing with green goo.
The Mutant Bacteria will attack. Be warned - Bacteria has a ton of HP. Fortunately, its defenses are pretty low, and it's vulnerable to status ailments. Stun the thing, then chip away at its health with fire, bleeding, anything you fancy. Not that tough a fight, though it may take a little while if you don't have some powerful attacks. Check the thing after it's dead for some small items, as well.
Canadian Barking Spider
The Canadian Barking Spider is found in, you guessed it, Canada. North of Ottawa you'll see a spider web set into a forest. Approach it and use the Poutine to summon the Spider.
The Canadian Barking Spider is strong, and its attacks can slow your characters, but as with the other hunting subjects it's weak to stunning. Put it out and your characters should have no trouble thwomping the thing. After beating it you'll find Barbarian Gloves.
Return to Jimbo's Guns after killing all six of the ferocious beasts. Jimbo will run through your achievements if you choose Big Game Hunting, and, all said, give you an Obsidian Shard and Jimbo's Key. You'll also earn Jimbo and Ned's friend requests. Use the alien eye on the right side of the shop to zip up to the chest above Ned; you can use the key you just got to pop it open and find $6.00, an axe of the underworld, a Grenade of Slowing, an Alaskan Whaler, a White Whale Patch, a Turtle Patch, and a Power Potion (Large). Woo!
Main Walkthrough